The Science Behind Our Products

Langerhans Cell and Skin Immunology

• Tang T. and Udey, MC., Dose of ultraviolet radiation that modulate accessory activity and ICAM-1 expression ate ultimately cytotoxic for murine epidermal Langerhans cells, J. Invest Dermol 1992, 99 71S-73S

• Dezutter-Dambuyant, C., Recent data and current studies of epidermal Langerhans cells, Pathol Biol (Paris) 1995 Dec; 43(10); 841-847.

• Dunlop, KJ., Halliday, GM., and Barnetson, RS., All-trans retinoic acid induces functional maturation of epidermal Langerhans cells and protects their accessory function from ultraviolet radiation, Exp. Dermatol 1994 Oct; 3(5): 204-211.

• Ghersetich, I, and Lotti, T., alpha-interferon cream restores decreased levels of Langerhans/indeterminate (CD1a+) cells in aged and PUVA-treated skin, Skin Pharmacol 1994; 7(3): 118-120.

• Cavanagh, LL., Sluyter, R., Henderson, KG., Barnetson, RS., and Halliday, GM. , Epidermal Langerhans’ cell induction of immunity against an ultraviolet-induced skin tumour, Immunology 1996 Mar; 87(3); 475-80.

• Cumberbatch, M., Dearman, RJ., and Kimber, I., Constitutive and inducible expression of interleukin-6 by Langerhans cells and lymph nod dendritic cells, Immunology, 1996 Apr; 87(4): 513-518.

• Williams, IR., and Kupper, TS., Immunity at the surface: homeostatic mechanisms of the skin immune system, Life Science 1996; 58(18): 1485-507.

• Schwarzenberger, K., and Udey, MC., Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ, Journal Investigative Dermatology 1996 Mar; 106(3): 553-558.

• Zulli, F, Applegate, LA, Frenk E and Suter F., Photoprotective effects of CM Glucan on cultured human skin cells, Eurocosmetics, 1995, 11, 46-50